Treatment-Resistant Depression (TRD)

When Nothing Seems to Work — We Offer New Hope

If you’ve tried multiple antidepressants, therapy, or other treatments and still feel stuck in depression, it can feel like there’s no way out. You may begin to question whether healing is even possible. At Alleviant Integrated Mental Health, we want you to know: there is still hope.

You may have Treatment-Resistant Depression (TRD) — a condition where traditional methods haven’t fully worked — but we specialize in advanced, personalized solutions that go beyond standard care. You are not broken — you just need a different path.

What Is Treatment-Resistant Depression?

Treatment-Resistant Depression is typically diagnosed when a person has not responded to at least two different antidepressant medications at adequate doses and duration. It can involve persistent symptoms of sadness, fatigue, hopelessness, disconnection, or emotional numbness, even while undergoing treatment.

TRD often exists alongside anxiety, trauma, sleep disorders, or brain-based imbalances that haven’t yet been identified or addressed.

You Deserve More Than Trial and Error

At Alleviant, we use Objective Psychiatry to provide measurable, personalized care. With spectral EEG (sEEG), we visualize your brain’s electrical activity — helping us detect dysregulation in mood centers, track your brain’s response to treatment, and guide you toward interventions that match your unique biology.

This data allows us to go beyond guesswork — and finally bring clarity to your care.

Advanced Treatment Options for TRD at Alleviant

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Comprehensive Psychiatry (In-Person or Telehealth)

Our psychiatric providers conduct a full diagnostic review and look beyond symptom labels. We consider your full history, genetic factors, medication trials, lifestyle, and EEG data to build a complete, actionable plan for long-term recovery.

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Medication Optimization

We offer pharmacogenetic testing to identify which medications may (or may not) work based on your DNA — reducing future trial-and-error. We also carefully adjust dosing and combinations with your full clinical picture in mind.

Spravato® (Esketamine)

Spravato® is an FDA-approved nasal spray used specifically for treatment-resistant depression. It works differently than traditional antidepressants, offering rapid symptom relief for some individuals — especially when depression is severe or includes suicidal thoughts. Administered under supervision in our clinics, Spravato can be a breakthrough for those who haven’t found relief elsewhere.

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Health Coaching (Telehealth)

Our health coaches help restore physical wellness, energy, and brain support by addressing nutritional imbalances that contribute to low mood and fatigue, toxic exposures (such as mold, inflammation, or chronic stress), and deficiencies in movement, sleep, hydration, or essential nutrients. We help build a resilient body to support a healing mind.

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Therapy (In-Person or Telehealth)

Talk therapy remains an essential component of care. We use Cognitive Behavioral Therapy (CBT), trauma-informed therapy, and other modalities tailored to your personal experience with chronic depression and frustration with past treatments.

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Spectral EEG (sEEG)

This fast, gel-free brain scan helps us visualize areas of under- or overactivation that may contribute to persistent depression. It becomes our objective baseline to guide TMS, medication decisions, and monitor improvement over time.

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Transcranial Magnetic Stimulation (TMS)

TMS is an FDA-cleared, non-invasive treatment that uses gentle magnetic pulses to stimulate specific areas of the brain involved in mood and anxiety regulation. At Alleviant, we follow established FDA protocols for depression, anxious depression, and OCD — ensuring safe, evidence-based care. In addition, we offer a fully personalized form of TMS known as NeuroSync™.

This advanced, off-label treatment is guided by your own spectral EEG (sEEG) data, allowing us to customize the frequency, intensity, and target areas based on your brain’s unique electrical activity. It’s psychiatry made smarter — tailored to you.

You’ve Tried So Much — It’s Time for Something Smarter

You haven’t failed treatment — treatment has failed you. Let’s change that.

If you feel like you’ve exhausted your options, we’re here to offer a new level of care — one that’s rooted in data, guided by empathy, and built around you.

Schedule Your Appointment

Let’s find what works — together. Schedule your consultation today by clicking below or call (866) 951-4325.

In-person and telehealth options are available.

Schedule an Appointment

Insurances Accepted

Logos of various health insurance companies including Aetna, Allwell, Ambetter, Arkansas Medicaid, Blue Cross Blue Shield, Cigna, GEHA, Humana, Magellan Health, Medicare, Optum, QualChoice, TRICARE, and UnitedHealthcare.

This is not an inclusive list as we are in-network with most major insurances.