Spravato® (Esketamine Nasal Spray) at Alleviant

If you’ve tried multiple medications and still feel stuck in depression, you’re not alone. Many people don’t respond fully to standard antidepressants — or feel numbed by them rather than truly healed.

At Alleviant, we offer Spravato®, an FDA-approved breakthrough treatment for adults with treatment-resistant depression and depression with suicidal thoughts. It works differently from traditional medications, offering new hope for those who haven’t found relief.

What Is Spravato®?

Spravato® is a nasal spray formulation of esketamine, a compound related to ketamine. It targets the glutamate system — a different neurotransmitter pathway than most antidepressants — and helps:

• Reduce depressive symptoms quickly (often within hours or days)

• Restore synaptic connections in the brain

• Support emotional flexibility and resilience

• Alleviate suicidal thinking (with additional care in place)

It is administered under medical supervision in a safe, comfortable setting at Alleviant clinics.

FDA-Approved For:

• Adults with treatment-resistant depression (TRD)

• Adults with major depressive disorder (MDD) who are experiencing suicidal ideation

Patients must also be taking an oral antidepressant during treatment.

What to Expect with Spravato® Treatment

1. Initial Evaluation & Clearance

   You’ll meet with an Alleviant psychiatric provider to determine if Spravato® is right for you. We’ll review your medical history, current symptoms, and treatment goals.

2. Supervised In-Clinic Sessions

   Spravato® is administered twice weekly (for the first 4 weeks), then reduced to weekly or biweekly. Each session lasts about 2 hours, and you’ll be monitored throughout.

3. Therapeutic Integration & Support

   Our team integrates Spravato® with your full treatment plan, which may include therapy, health coaching, and other brain-based interventions.

4. Ongoing Monitoring

   Your provider will adjust your frequency and plan as needed — always prioritizing your safety and long-term wellbeing.

Is Spravato® Right for Me?

This treatment may be an option if:

• You’ve tried at least two or more antidepressants with little or no relief

• You’re under the care of a provider and open to combining treatments

• You’re seeking a structured, supervised treatment that works through a new mechanism

Spravato® is not the same as ketamine infusions. It is FDA-approved, covered by many insurance plans, and only available through certified clinics.

Why Alleviant?

We integrate Spravato® into a whole-person mental health plan — never using it as a quick fix or standalone solution. Your care team may also include:

• Psychiatry and medication management

• Therapy or trauma work

• Health coaching

• Spectral EEG (sEEG) to track brain response

• Optional NeuroSync™ for long-term neuroplasticity