Ketamine works by increasing synaptogenesis and neuroplasticity, regulating glutamate, and decreasing inflammation.
Synaptogenesis is the formation of new synapses between neurons in the nervous system.
Neuroplasticity is the ability of the brain to form and reorganize synaptic connections, especially in response to new information, new experiences, or following an injury.
Glutamate is the primary fuel source for the central nervous system.
Inflammation is part of the body’s immune response, which serves as a defense system against infections.
A Little Bit About Your Brain
The human brain is made up of about 100 billion nerve cells, or neurons, that “talk” to each other through thread-like fibers (long transmission cables – axons, and short twiggy fibers – dendrites). Each neuron makes between one thousand to ten thousand points of contact, called synapses, with other neurons. Synapses allow information to be exchanged between neurons.
Our experiences reshape and modify our brains by strengthening and weakening synapses that link neurons together. For example, when the pattern “event B always happens after event A” is constantly being reinforced, the synapses between the neurons that represent A and neurons that represent B get strengthened. On the other hand, if A and B stop having any meaningful relationship with each other, the neurons that represent A and B will shut down their mutual connections to reflect this new reality.
Moreover, emotionally-charged experiences form stronger connections. Both positive and negative impressions have the potential to strengthen their path in the brain.
Our brains engage in neuroplasticity when we learn through repetition, creating new patterns, habits, and beliefs. On the flipside, we can lose a skill or belief when we don’t practice it often enough to keep the connections strong and active.
When positive connections atrophy and negative patterns and behaviors are reinforced, people often feel stuck in their depression with no hope for a way out.
The good news is that our brains are constantly re-shaping themselves, and, much like muscles, even the weakest positive connections can be strengthened with focused attention and repetition. Through therapy and positive psychology, you can learn new information and adopt new ways of looking at events in your life.
Harness the Power of Neuroplasticity With Ketamine
Ketamine helps you rewire your neural connections rapidly and safely by beginning a process leading to increased production of brain-derived neurotrophic factor (BDNF) – a protein that increases neuroplasticity and synaptogenesis. It creates a perfect foundation for your work with a therapist.
Ketamine for Mood Disorders
People affected with mood disorders frequently feel significantly better after receiving ketamine infusions. This is not because it tricks you into thinking you feel better. Ketamine helps repair the damage in the central nervous system caused by an incompetent NMDA receptor.
Ketamine, however, is not a cure for chronic disorders. Whatever caused the problem in the first place may still exist. Therefore, we work with you to find and heal the root cause and address your long-term needs. Ketamine infusions can be an amazing bridge to healing that quickly decreases symptoms.
Once Ketamine has kick-started the healing process in the central nervous system, you can achieve rapid progress in processing emotional trauma, introducing and learning new ways of thinking, and redirecting your energy towards positive momentum for your life.
Ketamine for Pain Conditions
During your infusion, ketamine works in your nervous system to help break cycles of chronic pain caused by nerve damage and faulty communication. Ketamine also has potent anti-inflammatory properties and increases circulation in the body, reducing joint pain brought on by swelling.
We administer low, controlled doses of ketamine through an IV infusion, and many patients find immediate relief from their chronic pain during their first infusion.
Glutamate is the primary fuel source of the central nervous system. Mood disorders, in part, may be the result of our central nervous system (CNS) not having enough glutamate.
The N-Methyl-D-Aspartate (NMDA) receptor is like a dam for Glutamate. In mood disorders, the NMDA receptor may be dysfunctional and may remain open, allowing glutamate to flow freely in a very uncontrolled state. This decreases the amount of glutamate upstream the NMDA receptor. When glutamate levels decrease to a critical level the AMPA receptor stops functioning correctly. The AMPA receptor is responsible for neurogenesis (the formation of new nerve cells), neuroplasticity (the correct alignment of neurons), and controlling inflammation in the CNS. As the AMPA receptor frequently turns off, neurons begin shriveling up and dying off and inflammatory processes become rampant.
Ketamine is a medication that works to slow down or stop the NMDA receptor from allowing the uncontrolled flow of glutamate through it. Ketamine selectively blocks the NMDA receptor which allows the CNS to fill back up with glutamate. Low dose intravenous Ketamine infusions only block the NMDA receptor for up to 72 hours. Therefore, multiple ketamine infusions are necessary to keep the NMDA receptor blocked until enough glutamate exists in the CNS to jump-start the AMPA receptor.
When the AMPA receptor is functional, it produces Brain-Derived Neurotrophic Factor (BDNF), which stimulates synaptogenesis, and increases neuroplasticity. In essence: it builds new neurons, helps neurons communicate effectively, and decreases inflammation.
We administer controlled sub-anesthetic doses of ketamine through an IV in our restorative, spa-like clinics under constant medical supervision. Infusions range from one to several hours, depending on the diagnosis, and patients describe their experiences as relaxing and peaceful.
With Ketamine Infusion Therapy, most people experience a rapid reduction in depressive symptoms and are left with feelings of love, compassion, and peace.
A study published in the International Journal of Transpersonal Studies describes the state of mind people experience during and after the infusion as “Increased psychological clarity, feelings of being cleansed, increased confidence, feelings of happiness and well-being, state of inner peace, feelings of detachment, motivation to improve oneself, and strong feelings of empathy for everyone.”
These effects are usually most pronounced immediately after an infusion but can last weeks or even months after treatment.
How Ketamine Infusion Therapy Works:
- Patients sit in a comfortable reclining chair in a dedicated room of our spa-like clinics.
- We administer sub-anesthetic dose of ketamine through an IV.
- Most infusions last around an hour, and patients describe their experiences as relaxing and peaceful.
- The national standard for treating mood disorders with ketamine infusions is for patients to complete six to ten infusions over the course of several weeks. With pain conditions, treatment recommendations vary per diagnosis and the severity of the problem, but many patients find immediate relief during their first infusion.
- Approximately 15-20% of our clients that undergo ketamine infusion therapy require maintenance infusions.
- This may range from once a month to once a year.
- It is impossible to predict who will need additional infusions or how often they may be needed.
- In our experience, 75% of clients experience significant reductions in symptoms.
- 65% experience sustained improvement in symptoms and do not come back for maintenance infusions.
- Acute migraine response success averages at 75%.
- For chronic migraine sufferers, the intensity, duration, and frequency are often decreased to the point where the client’s oral breakthrough medications are able to control the majority of future migraine headaches.
Ketamine IV vs Ketamine Nasal (Esketamine)
There are consensus statements from the American Psychiatric Association and the American Society of Anesthesiologists supporting utilizing IV ketamine for treatment resistant mood and neuropathic pain conditions.
Intravenous bioavailablity is superior to the nasal route. Hundreds of articles have been written in prestigious journals supporting IV ketamine’s cost effectiveness, safety, and efficacy in treatment resistant mood and chronic pain conditions. Patients undergoing IV ketamine treatments frequently decrease and/or eliminate multiple oral medications, including narcotics. Their quality of life improves and their healthcare costs decrease.
At the same time, no studies demonstrate that Esketamine is superior to racemic ketamine.